Lichen planus.
Conditions
Interventions
IMOD 400 mg daily for 3 months.
Treatment - Drugs
IMOD 400 mg daily for 3 months
Sponsors
Research center of dental Science of Tehran University of medical sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: clinical histopathologic diagnosis of lichen planus (Lichen planus diagnosis will be made with clinical criteria, consisting of the presence of symmetric reticular or papular lesions with or without erosive/atrophic or Bullous components. Histopathologic features of oral lichen palnus are: 1) Areas of hyperparakeratosis or hyperorthokeratosis, often with a thickening of the granular cell layer and a saw-toothed appearance to the retepages. 2) Liquefaction degeneration or necrosis of the basal layer. 3) A dense subepithelial band, shaped by infiltration of lymphocytes and macrophages. 4) Absence of dysplastic changes) Exclusion criteria: Any systemic disease, pregnancy and any other mucosal lesions
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical score. Timepoint: 2 weekly in the first month and then monthly for 6 months. Method of measurement: regesteration the primary scores of lesions and their changes on the follow up period as described in the matherial and methods. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain and discomfort in the oral lesion. Timepoint: 2 weekly in the first month and then monthly up to 6 month. Method of measurement: VAS scale as described in the matherial and method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Neda Akbary Gillani
Oral Medicine Department of Tehran University of Medical Siences
Outcome results
None listed