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Evaluation of efficacy of topical nitric oxide in treatment of cutaneous leishmaniasis

Comparison of efficacy of topical nitric oxide 3% and cryotherapy with cryotherapy and placebo in cutaneous leishmaniasis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT138710191535N1
Enrollment
100
Registered
2009-07-05
Start date
2007-09-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cutaneous leishmaniasis. Cutaneous leishmaniasis

Interventions

Intervention 1: Intervention: topical nitric oxide 3 percent 3 times a day + cryotherapy once a week for 12 weeks. Intervention 2: Control: placebo cream 3 times a day + cryotherapy once a week for 12
Treatment - Drugs
Intervention: topical nitric oxide 3 percent 3 times a day + cryotherapy once a week for 12 weeks
Control: placebo cream 3 times a day + cryotherapy once a week for 12 weeks

Sponsors

?Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: age more than 12 years, less than 5 active lesion, no topical treatment from 2 weeks prior to study and no systemic treatment from 1 month prior to study, Exclusion criteria: pregnancy and lactation, facial lesions, lesions with more than 4 months duration

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Complete improvement. Timepoint: Baseline, every other week. Method of measurement: measurment of erythema and induration diameter with a ruler.

Secondary

MeasureTime frame
Side effects. Timepoint: every other week. Method of measurement: medical history taking and physical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarideh Dehghani,MD

Shiraz University of Medical Science

farideh.dehghani@yahoo.com+98 71 1235 1087

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026