Major Depressive Disorder. Mild and Moderate Depressive Episode
Conditions
Interventions
Intervention 1: Fluoxetine, 30 mg, orally, (10 mg capsules tid) for 6 weeks. Intervention 2: 1200 mg dried extract from arial parts of Asperugo Procumbens L (18 mg total flavenoid) (400 mg dried extra
Treatment - Drugs
Fluoxetine, 30 mg, orally, (10 mg capsules tid) for 6 weeks
1200 mg dried extract from arial parts of Asperugo Procumbens L (18 mg total flavenoid) (400 mg dried extract or 6 mg total flavenoid capsules tid) for 6 weeks
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: DSM-IV criteria for major depressive disorder, Hamilton Depression Rating Scale score 18-25, Informed Consent Exclusion criteria: Intelligence quotient (IQ) less than 70, Positive history of bipolar mood disorder (BMD), consumption of psychostimulator agents in last 2 weeks, Serious medical disease, Allergic reaction to A.procumbens L., Psychotic depression, Positive history of suicidal attempt or suicidal intention, Pregnancy, Positive history of cognitive disorder during last year
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression. Timepoint: 2 weeks. Method of measurement: Hamilton Depression Rating Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects profile. Timepoint: 2 weeks. Method of measurement: Clinical interview and physical examination and checklist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehran Zarghami
Mazandaran University of Medical Sciences
Outcome results
None listed