acute coronay syndrome. Acute ischaemic heart disease, unspecified
Conditions
Interventions
Intervention 1: Patients in group 1 receive a bolus of 80 U/Kg and an initial infusion rate of 17 U/Kg/hr. APTT is controlled every 6 hours for 48 hours. The therapeutic level of aPTT is 46-70 s. If a
Treatment - Drugs
Patients in group 1 receive a bolus of 80 U/Kg and an initial infusion rate of 17 U/Kg/hr. APTT is controlled every 6 hours for 48 hours. The therapeutic level of aPTT is 46-70 s. If aPTT is in this r
Patients in the second group receive a bolus of 60 U/Kg (maximum 4000 U) and an initial infusion rate of 12 U/Kg/hr (maximum 900U/hr). aPTT is measured every 6 hours up to 48 hours. For aPTT,46-70 s,
Sponsors
Shahid Sadoughi University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: >18 years old; ACS; admission to CCU. Exclusion criteria: receiving thrombolytic drugs in the past week; current bleeding; history of thrombocytopenia with heparin; receiving heparin prior to hospitalization; thrombocytopenic patients.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| APTT in the therapeutic range (46-70 s). Timepoint: before infusion of heparin and every 6 hours until 48 hours after intervention. Method of measurement: standard methods of measuring aPTT. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of changes in the rate of heparin. Timepoint: every 6 hours until 48 hours after intevention. Method of measurement: observation.;Time to reach therapeutic aPTT. Timepoint: every 6 hours until 48 hours after intevention. Method of measurement: measuring time by watch. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRoghieh Atashkooh
Yazd cardiovascular research center
Outcome results
None listed