Comparison of two methods of analgesia after major surgical operations

Comparison of patient-controlled analgesia with morphine and target-controlled analgesia with sufentanil in controlling post-operative pain

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138707271361N1

Enrollment

Registered

2009-01-04

Start date

2008-12-30

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post operative analgesia. complication of medical and surgical care-opioids and related analgesics

Interventions

Intervention 1: Infusion of morphine as analgesic with PCA pump. Intervention 2: Infusion of sufentanil as analgesic with TCI pump.

Treatment - Drugs

Infusion of morphine as analgesic with PCA pump

Infusion of sufentanil as analgesic with TCI pump

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Having been carried out a major surgical operation, Being awake in postoperative period, Age 18-60, Exclusion criteria: Denial of patients, Depressed consciousness, Need for mechanical ventilation after operation, Dependence to opium or other sedatives like Benzodiazepines.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: every 2 hours until 24 hours after surgery. Method of measurement: Visual Analog Scale.	—

Secondary

Measure	Time frame
Nausea and Vomiting. Timepoint: every 2 hours until 24 hours after operation. Method of measurement: observation.;Level of Consciousness. Timepoint: every 2 hours until 24 hours after operation. Method of measurement: observation,clinical examination (GCS).;Pruritus. Timepoint: 24 hours after operation. Method of measurement: observation,clinical examination.;Hemodynamic changes. Timepoint: every 2 hours until 24 hours after operation. Method of measurement: clinical examination.;Rrespiratory Rate. Timepoint: every 2 hours until 24 hours after operation. Method of measurement: observation,clinical examination.	—

Measure

Time frame

Nausea and Vomiting. Timepoint: every 2 hours until 24 hours after operation. Method of measurement: observation.;Level of Consciousness. Timepoint: every 2 hours until 24 hours after operation. Method of measurement: observation,clinical examination (GCS).;Pruritus. Timepoint: 24 hours after operation. Method of measurement: observation,clinical examination.;Hemodynamic changes. Timepoint: every 2 hours until 24 hours after operation. Method of measurement: clinical examination.;Rrespiratory Rate. Timepoint: every 2 hours until 24 hours after operation. Method of measurement: observation,clinical examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSharareh Abdolmaleki

Imam Reza Hospital

nyeganeh@kums.ac.ir+98 83 1427 6309

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026