Comparison of Propofol and Thiopental in the treatment of refractory Status Epilepticus

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138707231349N1

Enrollment

Registered

2009-05-02

Start date

2008-09-12

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy. Status epilepticus

Interventions

Intervention 1: Thiopental: 1mg/kg/hour intravenous continous infusion. Intervention 2: Propofol: 2mg/kg/hour intravenous continous infusion.

Treatment - Drugs

Thiopental: 1mg/kg/hour intravenous continous infusion

Propofol: 2mg/kg/hour intravenous continous infusion

Eligibility

Sex/Gender

All

Age

No minimum to 18 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Refractory Status Epilepticus. Exclusion criteria: hypotension, hypoxia, sepsis, liver failure, renal failure, heart disease

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Convulsion control. Timepoint: During admission. Method of measurement: Time (hours) to stop convulsion.;Convulsion control. Timepoint: During admission (EEG every 24 hr). Method of measurement: Time (hours) to see burst suppression appearance on EEG.	—

Secondary

Measure	Time frame
Complication of treatment (metabolic acidosis, fatty liver, hypoxia). Timepoint: blood gas analyses: every hour, blood chemicals: twice a day, others: every other day. Method of measurement: labratory tests.;Time of mechanical ventilation. Timepoint: During admission. Method of measurement: Time (hours) of mecahanical ventilation.;PICU stay. Timepoint: During admission. Method of measurement: Number of PICU admission days.	—

Measure

Time frame

Complication of treatment (metabolic acidosis, fatty liver, hypoxia). Timepoint: blood gas analyses: every hour, blood chemicals: twice a day, others: every other day. Method of measurement: labratory tests.;Time of mechanical ventilation. Timepoint: During admission. Method of measurement: Time (hours) of mecahanical ventilation.;PICU stay. Timepoint: During admission. Method of measurement: Number of PICU admission days.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeedeh Haghbin

Shiraz University of Medical Sciences, Medical school

haghbins@sums.ac.ir+98 71 1647 4298

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026