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Effect of helicobacter pylori eradication on regression of gastric precancerous lesion in 1st degree relatives of patients with gastric cancer

Effect of helicobacter pylori eradication on regression of gastric precancerous lesion in 1st degree relatives of patients with gastric cancer

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT138706131155N2
Enrollment
480
Registered
2009-01-30
Start date
2004-08-05
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gasteric Cancer. Malignant neoplasm of stomach

Interventions

Intervention 1: Intervention group reciverd Omeprazol 20mg, Bismut 240mg, metronidazol 500mg,amoxicillin 1gr twice a day for 2 week. Intervention 2: Control group recived plasebo.
Intervention group reciverd Omeprazol 20mg, Bismut 240mg, metronidazol 500mg,amoxicillin 1gr twice a day for 2 week
Control group recived plasebo

Sponsors

Guilan Govermental Province
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1st degree relatives of patients with gastric cancer (father , mother, sister and brother. son and doughter), aged 40-65 years old, with gastritis, dont limit to antrum, and precancerous lesions with helicobacter pylori infection, giving informed consent. Exclusion criteria: cases of gastric cancer, peptic ulcer with endoscopic evidence, history of gasterctomy, chronic or serious medical diseases (renal failure, CHD, liver disease, etc )

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Eradication of helicobacter pylori. Timepoint: 6-8 weeks after treatment. Method of measurement: UBT.;Regression of precancerous lesions. Timepoint: one year after onset of treatment. Method of measurement: endoscopy and pathology.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarahnaz Joukar

Gastrointestinal and Liver Diseases Research Center

F_Jokar@gums.ac.ir+98 13 1553 5116

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026