The Pattern of Opioid Withdrawal Signs and Symptoms in Three Groups

The Pattern of Opioid Withdrawal Signs and Symptoms in Three Groups: 1. Patients undergoing Clonidine Abstinence Therapy, 2. Patients on starting clinical dose of Methadone Maintenance Therapy (MMT), and 3. Patients admitted for short-time detoxification with Methadone in Opioid Addict Subjects who were Referred to Imam-Reza Hospital Rehabilitation Center and Toxicology Ward – Mashhad from November 2008 to October 2009

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT138706121187N1

Enrollment

Registered

2010-01-09

Start date

2008-11-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioid Addiction. Mental and behavioural disorders due to use of opioids,withdrawal state

Interventions

Intervention 1: In the first group, patients are given Clonidine 0.1 mg per oral q 12 hours, Benzodiazepine (Chlorodiazepoxide 10mg at 6 Am, 10 mg at 2 Pm and 20 mg at 10 Pm per oral), Indomethacin 10

Treatment - Drugs

In the first group, patients are given Clonidine 0.1 mg per oral q 12 hours, Benzodiazepine (Chlorodiazepoxide 10mg at 6 Am, 10 mg at 2 Pm and 20 mg at 10 Pm per oral), Indomethacin 100 mg if necessar

Patients on Methadone Maintenance Therapy (MMT) for 45 days, are given Methadone 40 mg per oral in the first day and then this dose will be increased 5 mg daily for disappearing the withdrawal signs a

The patients in the third group, are given Methadone 10 mg in the first day, 5 mg in the second and third day and nothing in the forth and fifth day, and also Maintenance serum of ?? 2 Lit daily IV if

Eligibility

Sex/Gender

Male

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: will to enter the study, Having no positive history of a psychological disorder, Not using any psychological either neurological drugs, Having no positive history of a cardiovascular disease, Being male, age between 18 to 60 years old Exclusion criteria: Discontinuing the treatment, Leaving the hospital sooner than the proper time

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Less opioid withdrawal signs and symptoms. Timepoint: Daily. Method of measurement: The Pattern of Opioid Withdrawal Signs and Symptoms using Fultz chart.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Reza Afshari

Mashhad University of Medical Sciences

afsharir@mums.ac.ir,javidida811@mums.ac.ir+98 51 1859 8973

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026