Anesthetic efficacy of intraoral mucoadhesive Amitriptyline in healthy volunteers.
Conditions
Interventions
The right or left labial alveolar mucosa of the upper incisor apices will be used for topical anesthesia application. The side will be randomly determined with the table of random numbers. The mucoadh
Sponsors
Tehran university of medical sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Women between the ages of 20 and 40 years Exclusion criteria included systemic conditions (such as cardiovascular diseases, diabetes, renal insufficiency, hepatic dysfunction …..), allergic reactions to antidepressants, pregnancy, history of nerve injury, receiving drugs, neuropathy
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthetic. Timepoint: 15, 30, 45 minutes after removal patches. Method of measurement: The pain rating score (PRS) and visual analog scale (VAS) will be measured after insertions of a 27-gauge needle. | — |
Secondary
| Measure | Time frame |
|---|---|
| . Timepoint: At 30 minutes and 24 and 48 hours after the removal of the patch. Method of measurement: Local irritation will be rated as follows: 0 = no irritation, 1 = minimal (blood vessels raised above normal levels), 2 = moderate (beet redness of mucosa, individual blood vessels not discernible) and 3 = severe (blister formation and necrosis evident). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMojgan Alaeddini
Dental Reasearch Center
Outcome results
None listed