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Effects of intranasal amphotericin-B Irrigation on recurrence of massive nasal polyposis

Effects of intranasal amphotericin-B Irrigation on recurrence of massive nasal polyposis after endoscopic sinus surgery and comparison with nasal corticosteroid sprays

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT138706101138N1
Enrollment
96
Registered
2010-09-30
Start date
2010-08-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nasal polyposis. Nasal polyp

Interventions

Intervention 1: amphotericin B solution. Intervention 2: nasal Becklometazone Spray.
Treatment - Drugs
amphotericin B solution
nasal Becklometazone Spray

Sponsors

Guilan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 75 Years

Inclusion criteria

Inclusion criteria: The study population consists of patients more than 15 years old residents of Guilan province who have extensive nasal polyposis and their diseases are diagnosed based on physical examination, diagnostic nasal endoscopy, and CT scan of paranasal sinuses. Only those patients who would complete the 4 months course of drug therapy and undergo the follow- up visits, will enter in the study. Those patients who are depended to corticosteroid drugs, pregnant or breast-feeder women, mental retard cases, or patients with speech or behavioral disorders will be excluded from the study. Every patients who enter the study must fulfill informed consent.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Recurrence of nasal poliposis. Timepoint: one week- one month- monthly up to 3 months. Method of measurement: clinical examination- diagnostic endoscopic.

Secondary

MeasureTime frame
Respiratory problems. Timepoint: end of 4th month. Method of measurement: questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr shadman nemati

Guilan University of medical sciences

entrc@gums.ac.irnemati@gums.ac.ir+98 13 1222 5242

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026