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Effect of Zinc and Folic Acid on semen analysis and sperm function

Effect of Zinc and Folic Acid on sperm function test in infertile men

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT138706091079N2
Enrollment
100
Registered
2011-07-18
Start date
2007-05-31
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male Infertility. Male infertility

Interventions

220 mg/day, Oral Route, 16 weeks duration
Folic acid / Zinc Folic acid
5 mg/day, Oral Route, 16 weeks duration Placebo
220 mg/day, Oral Route, 16 weeks duration.
Treatment - Drugs
Placebo
Zinc / placebo Zinc
220 mg/day, Oral Route, 16 weeks duration Placebo
5 mg/day, Oral Route, 16 weeks duration
Folic acid / placebo Folic acid
Intervention 1: Zinc / placebo Zinc
220 mg/day, Oral Route, 16 weeks duration Placebo
5 mg/day, Oral Route, 16 weeks duration. Intervention 2: Folic acid / placebo Folic acid
5 mg/day, Oral Route, 16 weeks duration Placebo
220 mg/day, Oral Route, 16 weeks duration. Intervention 3: Folic acid / Zinc Folic acid
5 mg/day, Oral Route, 16 weeks duration Zinc
220 mg/day, Oral Route, 16 weeks duration. Intervention 4: placebo / placebo Placebo
5 mg/day, Oral Route, 16 weeks duration Placebo

Sponsors

Academic Center for Education and Culture and Research
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: inclusion criteria:infertile men with oligoasthenoteratozoospermia, 20-45 years old exclusion criteria: men with severe and chronic underlaying disease such as dibet, SC disabilities.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Sperm function test. Timepoint: before treatment commence and 16 weeks after treatment. Method of measurement: sperm function tests according to WHO standard.;Semen analysis. Timepoint: before treatment commence and 16 weeks after treatment. Method of measurement: routine semen analysis according to WHO standard.—

Secondary

MeasureTime frame
Total antioxidant capacity (TAC). Timepoint: 16 weeks after treatment. Method of measurement: spectrophotometry.;Reactive oxygen species (ROS). Timepoint: 16 weeks after treatment. Method of measurement: chemiluminescence.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Sadeghi

Avicenna Resaerch Institute

sadeghi@avicenna.ac.ir+98 21 2243 2024

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026