Serum biomarkers in periodontal therapy. Chronic periodontitis
Conditions
Interventions
Standard non-surgical periodontal therapy within two appointments including scaling and root planning with simultaneous lavage of chlorhexidine 0.1% from the tip of ultrasonic instrument into the pock
Treatment - Drugs
Sponsors
Guilan Universoty of Medical Sciences, Pro-vice-chancellor for research
Eligibility
Sex/Gender
All
Age
19 Years to 56 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Being systemically healthy, No history of previous periodontal therapy and antibiotic use during the past three months, Body mass index between 20-27, Existence of at least 20 standing teeth without untreated periapical lesions, At least 15% of sites with more than or equal to 5 mm of clinical attachment loss and pocket depth. Radiographic evidence of bone loss Exclusion criteria: Drugs such as: anticoagulants, steroids, anti-inflammatory drugs, immunosuppressant drugs, statins. Systemic diseases or conditions such as: Arthritis, GI disorders, skin diseases, bronchitis, Diabetes Mellitus, pregnancy, breast feeding and smoking.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum CRP levels. Timepoint: Before and four months after the intervention. Method of measurement: hs-CRP, by Enzyme- linked immunosorbent assay(ELIZA).;Plasma fibrinogen levels. Timepoint: Before and four months after the intervention. Method of measurement: Digital coagulation technique.;White blood cell counts. Timepoint: Before and four months after the intervention. Method of measurement: Counts in the peripheral blood samples. | — |
Secondary
| Measure | Time frame |
|---|---|
| Probing pocket depth. Timepoint: Before and four months after intervention. Method of measurement: Williams periodontal probe calibrated in millimeters with probe tip of 0.4 mm in width.;Clinical Attachment Level. Timepoint: Before and four months after the intervention. Method of measurement: Williams periodontal probe calibrated in millimiters with a probe tip of 0.4mm width.;Plaque index scores. Timepoint: Before and four months after intervention. Method of measurement: Plaque index OLeary.;Gingival index. Timepoint: Before and four months after intervention. Method of measurement: Lenox & Kopezyk bleeding points index. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGolpar Radafshar
Guilan University of Medical Sciences, School of Dentistry
Outcome results
None listed