Co Q10 and Semen parameter

Effect of Ubiquinone Supplementation on Semen Quality, Antioxidant Enzyme, Oxidative Stress and DNA Fragmentation in infertile men

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138706031079N1

Enrollment

Registered

2011-08-09

Start date

2008-07-31

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male Infertility. Male infertility

Interventions

Intervention 1: Co Q10 supplement: 2 (100 mg) per day (200 mg), 3 month,. Intervention 2: Placebo (lactose): 2 capsule per day, 3 month.

Treatment - Drugs

Co Q10 supplement: 2 (100 mg) per day (200 mg), 3 month,

Placebo (lactose): 2 capsule per day, 3 month

Eligibility

Sex/Gender

Male

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion : idiopathic oligoasthenoteratospermia, normal profile for hormones, normal genital anatomy Exclusion: major infection in genital organ, treatment for systemic disease during the last three months of inclusion, surgery background on genitalia, exposure to chemicals ,solvents or heavy metals, supplementation therapy in last three months of inclusion

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Semen analysis. Timepoint: 45 days , 90days. Method of measurement: HPLC, flourometry , spectrophotometry, ELIZA.;Sperm Isoprostan concentration. Timepoint: 45 days , 90days. Method of measurement: ELIZA.;Activity of seminal plasma catalase. Timepoint: 45 days , 90days. Method of measurement: spectrophotometry.;Activity of seminal plasma superoxide dysmutase. Timepoint: 45 days , 90days. Method of measurement: spectrophotometry.;Seminal plasma ubiquinone concentration. Timepoint: 45 days , 90days. Method of measurement: HPLC.;DNA fregmentation. Timepoint: 45 days , 90days. Method of measurement: Flowcytometry.	—

Measure

Time frame

Semen analysis. Timepoint: 45 days , 90days. Method of measurement: HPLC, flourometry , spectrophotometry, ELIZA.;Sperm Isoprostan concentration. Timepoint: 45 days , 90days. Method of measurement: ELIZA.;Activity of seminal plasma catalase. Timepoint: 45 days , 90days. Method of measurement: spectrophotometry.;Activity of seminal plasma superoxide dysmutase. Timepoint: 45 days , 90days. Method of measurement: spectrophotometry.;Seminal plasma ubiquinone concentration. Timepoint: 45 days , 90days. Method of measurement: HPLC.;DNA fregmentation. Timepoint: 45 days , 90days. Method of measurement: Flowcytometry.

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Secondary

Measure	Time frame
Seminal plasma gluthation reductase. Timepoint: 45 days, 90 days. Method of measurement: spectrophotometry.;Total Antioxidant Capacity(TAC). Timepoint: 45 days, 90 days. Method of measurement: spectrophotometry.;Seminal plasma Coenzyme Q10. Timepoint: 45 days, 90 days. Method of measurement: HPLC.;Seminal plasma gluthation peroxidase. Timepoint: 45 days, 90 days. Method of measurement: spectrophotometry.	—

Measure

Time frame

Seminal plasma gluthation reductase. Timepoint: 45 days, 90 days. Method of measurement: spectrophotometry.;Total Antioxidant Capacity(TAC). Timepoint: 45 days, 90 days. Method of measurement: spectrophotometry.;Seminal plasma Coenzyme Q10. Timepoint: 45 days, 90 days. Method of measurement: HPLC.;Seminal plasma gluthation peroxidase. Timepoint: 45 days, 90 days. Method of measurement: spectrophotometry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Sadeghi

Avicenna Resaerch Institute

sadeghi@avicenna.ac.ir+98 21 2243 2024

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026