Growth hormone deficiency in children.
Conditions
Interventions
Intervention 1: treatment intervention by 0.04 mg/kg/day Samen recombinant growth hormone in subcutaneous way for one year in intervention group. Intervention 2: treatment intervention by daily subcu
Treatment - Drugs
treatment intervention by 0.04 mg/kg/day Samen recombinant growth hormone in subcutaneous way for one year in intervention group
treatment intervention by daily subcutaneous injection 30 microgram/kilogram weight of NOVO recombinant growth hormone for one year in control group
Sponsors
Pharmacy CO. Samen
Eligibility
Sex/Gender
All
Age
7 Years to 13 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: 1-Pre-pubertal stage 2-Height standard deviation score<-3 3-Insulin growth factor-1 inappropriate for age & sex (low) 4-Growth hormone level post stimulating test by clonidine <10 ng/ml 5-Rule out of the other causes of growth hormone deficiency exclusion criteria: 1-Acute disorders such as seizure, infection diseases 2-Turner syndrome 3-Chronic kidney disease 4-Usage prednisolone
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Growth velocity. Timepoint: 1 year. Method of measurement: assessment height, puberty status. | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin growth factor-1,bone age. Timepoint: 6 month. Method of measurement: blood sample, radiology. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed