Influence of sevoflurane and propofol on maximum muscular strength, speed of contraction and relaxation.

Influence of sevoflurane and propofol on maximum muscular strength, speed of contraction and relaxation, in humans: A pilot study.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2022-003737-19-BE

Enrollment

Registered

2022-11-29

Start date

2023-01-10

Completion date

Unknown

Last updated

2024-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impact of anesthetic drugs on neuromuscular transmission

Interventions

Trade Name: Sévorane Pharmaceutical Form: Inhalation vapour, liquid INN or Proposed INN: Sevoflurane CAS Number: 28523-86-6 Concentration unit: % percent Concentration type: equal Concentration number

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Patients (male or female) from 18 – 80 years - Scheduled for surgery without the use of neuromuscular blocking agents - Health care insurance in Belgium - Written informed consent Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 36 F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range 12

Exclusion criteria

Exclusion criteria: - Any pathology involving neuromuscular transmission - Confirmed neuropathy of any origin - Expected anesthesia duration 1.5 * normal value of hepatic enzymes - Confirmed or suspected pregnancy - Language barrier - Any patient which will receive unplanned neuromuscular blocking agents during surgery - Any history of personal or familial suspected malignant hyperthermia

Design outcomes

Primary

Measure	Time frame
Main Objective: In this study, we want to measure the influence of sevoflurane and propofol on the maximum force, maximum speed of contraction and relaxation at the adductor pollicis (muscle of the thumb).;Secondary Objective: Not applicable;Primary end point(s): Maximum force, maximum speed of contraction and relaxation at the adductor pollicis (muscle of the thumb).;Timepoint(s) of evaluation of this end point: Before and after anesthesia by either sevoflurane or propofol	—

Measure

Time frame

Main Objective: In this study, we want to measure the influence of sevoflurane and propofol on the maximum force, maximum speed of contraction and relaxation at the adductor pollicis (muscle of the thumb).;Secondary Objective: Not applicable;Primary end point(s): Maximum force, maximum speed of contraction and relaxation at the adductor pollicis (muscle of the thumb).;Timepoint(s) of evaluation of this end point: Before and after anesthesia by either sevoflurane or propofol

—

Secondary

Measure	Time frame
Secondary end point(s): Not applicable;Timepoint(s) of evaluation of this end point: Not applicable	—

Countries

Belgium

Contacts

Public ContactAnesthesiology Department

CHU Brugmann

Christianerebecca.DZECHI@chu-brugmann.be3224773996

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026