Investigation of changes in the structure and function of the brain in musicians using magentic resonance tomography

Investigation of SSRI induced neuroplastic changes in musicians using functional magnetic resonance imaging

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2020-000160-28-AT

Enrollment

Registered

2020-07-14

Start date

2020-08-28

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Focal dystonia in musicians

Interventions

Trade Name: Cipralex Pharmaceutical Form: Tablet INN or Proposed INN: escitalopram Other descriptive name: ESCITALOPRAM OXALATE Concentration unit: mg milligram(s) Concentration type: equal Concentrat

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Diagnosis of primary focal upper extremity dystonia - General health based on medical history, physical examination and structured clinical interview for DSM-IV (SCID) - Age 18 to 60 years - Willingness and competence to sign the informed consent form. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 80 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: - History of any neurological or psychiatric disease (other than focal dystonia) - Any unstable medical condition - Injection of botulinum toxin A within the past 3 months - Current of former substance abuse - Psychopharmacological treatment within 3 months prior to inclusion - Pregnancy - Any implant or stainless steel graft or any other contraindications for MRI. - Body mass index 30 (Erritzoe, Frokjaer et al. 2010) - Failure to comply with the study protocol or to follow the instruction of the investigating team.

Design outcomes

Primary

Measure	Time frame
Main Objective: To investigate the influence of SSRI treatment adjunctive to conventional retraining on focal dystonia in pianists;Secondary Objective: To investigate neuroplastic changes following SSRI treatment adjunctive to conventional retraining in focal dystonia in pianists. ;Primary end point(s): symptom improvement;Timepoint(s) of evaluation of this end point: at screening, after 6 months of treatment	—

Measure

Time frame

Main Objective: To investigate the influence of SSRI treatment adjunctive to conventional retraining on focal dystonia in pianists;Secondary Objective: To investigate neuroplastic changes following SSRI treatment adjunctive to conventional retraining in focal dystonia in pianists. ;Primary end point(s): symptom improvement;Timepoint(s) of evaluation of this end point: at screening, after 6 months of treatment

—

Secondary

Measure	Time frame
Secondary end point(s): brain structure, brain activity and connectivity, task performance;Timepoint(s) of evaluation of this end point: each MRI measurement	—

Countries

Austria

Contacts

Public ContactNeuroimaging Labs

Medical University of Vienna

00431404003574

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026