Comparison of the number of oocytes obtained by performing ovarian stimulation at the time of the menstrual cycle that is usually done with performing it at a later stage of the cycle in patients who have previously had a poor response

CONVENTIONAL STIMULATION IN FOLICULAR PHASE VS. STIMULATION IN LUTEA PHASE IN PATIENTS WITH SUBOPTIMA RESPONSE. RANDOMIZED CLINICAL TRIAL. SUBLUTEAL STUDY

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2019-001342-18-ES

Enrollment

Registered

2019-04-30

Start date

2019-08-19

Completion date

Unknown

Last updated

2022-05-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Suboptimal response of ovarian stimulation

Interventions

Trade Name: Elonva Pharmaceutical Form: Injection INN or Proposed INN: CORIFOLLITROPIN ALFA CAS Number: 195962-23-3 Current Sponsor code: Org 36286 Concentration unit: µg microgram(s) Concentration ty

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 338/5000 1. Less than 10 oocytes in a conventional pre-controlled ovarian stimulation protocol 2. Age =65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: 1. Presence of follicles larger than 10 mm in the randomization visit 2. Endometriosis III / IV 3. Bologna criteria: patients with less than 4 oocytes in a previous ovarian stimulation and poor ovarian reserve parameters 4. Concurrent participation in another study

Design outcomes

Primary

Measure	Time frame
Main Objective: Study the difference in the number of oocytes obtained by performing ovarian stimulation in the follicular phase vs. Luteal phase in a population of patients with a suboptimal prior response.;Secondary Objective: • To evaluate if there are differences between both groups in terms of duration of stimulation • To Study of the differences between both groups regarding the consumption of gonadotropins and the cost of treatment • To Evaluate if there are differences between both groups in the cancellation rate of the stimulation cycle • To Evaluate if there are differences between both groups regarding the metaphase stage oocyte rate II • To Evaluate if there are differences between both groups in the rate of survival in the thawing and rate of fertilization after microinjection.;Primary end point(s): Number of cumulo oocyte complexes obtained;Timepoint(s) of evaluation of this end point: At the end of the menstrual cycle	—

Measure

Time frame

Main Objective: Study the difference in the number of oocytes obtained by performing ovarian stimulation in the follicular phase vs. Luteal phase in a population of patients with a suboptimal prior response.;Secondary Objective: • To evaluate if there are differences between both groups in terms of duration of stimulation • To Study of the differences between both groups regarding the consumption of gonadotropins and the cost of treatment • To Evaluate if there are differences between both groups in the cancellation rate of the stimulation cycle • To Evaluate if there are differences between both groups regarding the metaphase stage oocyte rate II • To Evaluate if there are differences between both groups in the rate of survival in the thawing and rate of fertilization after microinjection.;Primary end point(s): Number of cumulo oocyte complexes obtained;Timepoint(s) of evaluation of this end point: At the end of the menstrual cycle

—

Secondary

Measure	Time frame
Secondary end point(s): • Number of metaphase II stage oocytes obtained Duration of stimulation (days) • Cancellation fee • Fertilization rate • Dosage of medication used • Cost of oocyte treatment obtained;Timepoint(s) of evaluation of this end point: At the end of the menstrual cycle	—

Countries

Spain

Contacts

Public ContactAnna Pitas

Instituto Bernabeu

apitas@institutobernabeu.com

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026