Efficacy of a blood derivative (leukocyte and platelet rich fibrin) in healing after extraction of lower wisdom teeth.

Healing efficacy after impacted mandibular third molar surgery with the use of autologous platelet-rich fibrin: a randomized controlled clinical study

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2019-000902-31-ES

Enrollment

Registered

2019-07-05

Start date

2019-09-05

Completion date

Unknown

Last updated

2019-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

If the addition of L-PRF reduces postoperative pain and inflammation, as well as complications, after extraction of lower third molars

Interventions

Product Name: L-PRF Product Code: IS220 Pharmaceutical Form: Periodontal insert INN or Proposed INN: Leukocytes and platelet rich fibrin

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients> 18 years. Presence of oral health (periodontally healthy or with treated periodontitis), with a BoP =65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Patients who due to systemic conditions are not possible to draw blood. Penicillin allergy. Allergy to ibuprofen and / or paracetamol. Diseases that limit the use of ibuprofen and / or paracetamol.

Design outcomes

Primary

Measure	Time frame
Main Objective: To evaluate the efficacy of L-PRF placement in post-extraction alveoli when reducing postoperative pain after extraction of lower third molars against natural healing using a visual analogue scale (VAS).;Secondary Objective: Evaluate the level of inflammation using the Pasqualini index, the level of healing using the Landry index, the possible complications (osteitis, trismus, ...) and the number of analgesics needed.;Primary end point(s): Intensity of postoperative pain measured by an Analog Visual Scale;Timepoint(s) of evaluation of this end point: At 1, 2, 3, 4, 5, 6 and 7 day	—

Measure

Time frame

Main Objective: To evaluate the efficacy of L-PRF placement in post-extraction alveoli when reducing postoperative pain after extraction of lower third molars against natural healing using a visual analogue scale (VAS).;Secondary Objective: Evaluate the level of inflammation using the Pasqualini index, the level of healing using the Landry index, the possible complications (osteitis, trismus, ...) and the number of analgesics needed.;Primary end point(s): Intensity of postoperative pain measured by an Analog Visual Scale;Timepoint(s) of evaluation of this end point: At 1, 2, 3, 4, 5, 6 and 7 day

—

Secondary

Measure	Time frame
Secondary end point(s): Inflammation level according to Pasqualini's Visual scale. Level of healing according to the Landry index. Postoperative complications: trismus and / or osteitis. Number of analgesic pills needed. ;Timepoint(s) of evaluation of this end point: 7 day	—

Countries

Spain

Contacts

Public ContactMaster of Periodontics. USC

University of Santiago de Compostela. Faculty of Medicine and Dentistry

anacastellanoviruleg@gmail.com34981562226

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026