Healthy volunteers
Conditions
Interventions
Trade Name: Miochol-E
Product Name: Acetylkohlin
Pharmaceutical Form: Intraocular instillation solution
Pharmaceutical form of the placebo: Concentrate
Sponsors
Region Östergötland
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Age between 18 and 45 years Generally healthy and without medication No skin disease or other skin conditions Voluntary participation in the study Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 105 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range 0
Exclusion criteria
Exclusion criteria: The person doesn’t understand the oral or written information. Ongoing medication of any form, except contraceptives. Known hypertension, skin disease, cardiovascular disease, ongoing pregnancy. Damaged skin, bruises, scar tissue or tattoos on the forearm skin Smoker (has smoked within 6 months or smoked more than 100 cigarettes). Snusing (has been snus within 6 months). The research person has used nicotine preparations (chewing gum, patches, etc.) within the last 6 months Blood pressure above 140/90. No coffee, tea, alcoholic beverages or hard physical activity on the day of the trial Not fasting 2 hours before the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To study in vivo dose-responses of vasoactive drugs administred by iontoforesis.;Secondary Objective: Not applicable.;Primary end point(s): ED50, minimum value, maximum value and hill slope (from the dose-response curve); Timepoint(s) of evaluation of this end point: Is measured continuously, at one minute intervals, before, during and after the iontophores. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end point(s): None;Timepoint(s) of evaluation of this end point: N/A | — |
Countries
Sweden
Contacts
Public ContactJoakim Henricson
Region Östergötland
Outcome results
None listed