Effect of intramuscular corticosteroid injection on the post-operative swelling, trismus and pain following lower third molar surgery

Effect of preoperative intramasseteric methylprednisolone injection on the post-operative sequelae of lower third molar surgery: a placebo controlled, randomized, double-blinded study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2018-004083-62-HU

Enrollment

Registered

2019-07-05

Start date

2019-09-06

Completion date

Unknown

Last updated

2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post-operative swelling, trismus, pain

Interventions

Trade Name: Solu-Medrol Pharmaceutical Form: Powder and solution for solution for injection Pharmaceutical form of the placebo: Solution for injection/infusion Route of administration of the placebo:

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: -on both sides existing lower wisdom teeth, in deeper impaction and similar position -between the age of 18 and 50 -healthy -not receiving any medication that can affect the treatment -good oral hygiene Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 30 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: -smoking -poor oral hygiene -receiving medication that can affect the treatment -disease or general state that can affect the treatment -symptoms of inflammation in the surgical area -if the patient can not appear on the control examinations

Design outcomes

Primary

Measure	Time frame
Main Objective: The objective of this study is to evaluate the efficacy of intramasseteric corticosteroid (methylprednisolone) injection on post-operative swelling, trismus and pain after mandibular impacted third molar surgery.;Secondary Objective: To evaluate the efficacy of intramasseteric corticosteroid (methylprednisolone) injection on post-operative trismus and pain.;Primary end point(s): -;Timepoint(s) of evaluation of this end point: -	—

Measure

Time frame

Main Objective: The objective of this study is to evaluate the efficacy of intramasseteric corticosteroid (methylprednisolone) injection on post-operative swelling, trismus and pain after mandibular impacted third molar surgery.;Secondary Objective: To evaluate the efficacy of intramasseteric corticosteroid (methylprednisolone) injection on post-operative trismus and pain.;Primary end point(s): -;Timepoint(s) of evaluation of this end point: -

—

Secondary

Measure	Time frame
Secondary end point(s): -;Timepoint(s) of evaluation of this end point: -	—

Countries

Hungary

Contacts

Public ContactSemmelweis University, Oro-Maxillof

Semmelweis University, Oro-Maxillofacial Surgery and Stomatology

titkarsag.arcallcsont@dent.semmelweis-univ.hu+3612660457

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026