Characterization of a macrophage population under the control of nerves in the gastrointestinal tract

Characterization of nerve-modulated macrophage population in the gastrointestinal tract

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2018-002192-18-BE

Enrollment

Registered

2018-08-16

Start date

2018-09-14

Completion date

Unknown

Last updated

2024-06-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing colorectal surgery due to benign or malignant carcinoma, diverticulitis or constipation drug will be used to differentiate between macrophages that are modulated by enteric neurons and those that are not

Interventions

Trade Name: Resolor Product Name: Resolor Pharmaceutical Form: Film-coated tablet INN or Proposed INN: Prucalopride CAS Number: 179474-81-8 Other descriptive name: PRUCALOPRIDE SUCCINATE Concentration

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients above 18 years old undergoing colorectal surgery due to benign or malignant carcinoma, diverticulitis or constipation Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 5 F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range 5

Exclusion criteria

Exclusion criteria: • Adjuvant radiotherapy • Evident intra-abdominal inflammation (diagnosed by CT/RX or lab results) • ‘American Society of Anesthesiologists physical-health status classification’ (ASA-PS) >3 • Uncontrolled diabetes (>200 mg/dl (=11mmol/l))

Design outcomes

Primary

Measure	Time frame
Main Objective: Characterization of the macrophage population subset that is modulated by enteric neurons;Secondary Objective: Not applicable;Primary end point(s): Characterization of the macrophage population subset that is modulated by enteric neurons via RNA sequencing;Timepoint(s) of evaluation of this end point: Not applicable	—

Secondary

Measure	Time frame
Secondary end point(s): Not applicable;Timepoint(s) of evaluation of this end point: Not applicable	—

Countries

Belgium

Contacts

Public ContactGuy Boeckxstaens

KU Leuven

16342883

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026