Depression The main aim of this study is to understand how N2O affects - during gas exposure and upon gas withdrawal - slow EEG oscillations in healthy adult volunteers. The aim is to understand the individual variation to the treatments, the dose-response effects of the treatments and the effect of intermittent dosing of the treatments on EEG.
Conditions
Interventions
Trade Name: Nitrous oxide
Product Name: Nitrous oxide
Pharmaceutical Form: Inhalation vapour
Sponsors
Tampere University Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 18-40 years, BMI 18-27 Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 40 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: no medication/chronic illness, no previous history of psychiatric or substance abuse disorders,
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: The main aim of this study is to understand how N2O affects - during gas exposure and upon gas withdrawal - slow EEG oscillations in healthy adult volunteers. ;Secondary Objective: The impact of the treatments on cognitive functions and psychological state ;Primary end point(s): Slow wave oscillations (EEG) ;Timepoint(s) of evaluation of this end point: During administration and directly after administration | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end point(s): Cantab, SCL90 ;Timepoint(s) of evaluation of this end point: Directly after administration | — |
Countries
Finland
Contacts
Public ContactSimo Varila
Tampere University Hospital
Outcome results
None listed