Can Paracetamoil Ease the Pain of Social Rejection?

Can Acetaminophen Ease the Heartbreak of Social Rejection? - ParaHart Study

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2017-004735-37-NL

Enrollment

Registered

2018-01-24

Start date

2018-03-05

Completion date

Unknown

Last updated

2018-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy participants

Interventions

Trade Name: Paracetamol Product Name: Paracetamol Pharmaceutical Form: Tablet Pharmaceutical form of the placebo: Tablet Route of administration of the placebo: Oral use

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: 1. Age between 18 and 30 2. Sufficient understanding of Dutch Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 72 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: 1. Cardiac, hepatic, renal, neurological or psychiatric disorders 2. Personal or family history of depression 3. Migraine 4. Drug use and medication use

Design outcomes

Primary

Measure	Time frame
Main Objective: The main goal of the present study is to examine whether acetaminophen decreases the cardiac response to unexpected social rejection in a social evaluation task. ;Secondary Objective: Secondary goals are how acetaminophen affects the subjective evaluation of social rejection, the brain response to social evaluation and the expectation bias in the social judgment task. Finally we are interested in how acetaminophen affects crying behaviour as subjectively indicated by the participants. ;Primary end point(s): Cardiac deceleration following unexpected social rejection;Timepoint(s) of evaluation of this end point: 1 hour after ingestion of paracetamol	—

Measure

Time frame

Main Objective: The main goal of the present study is to examine whether acetaminophen decreases the cardiac response to unexpected social rejection in a social evaluation task. ;Secondary Objective: Secondary goals are how acetaminophen affects the subjective evaluation of social rejection, the brain response to social evaluation and the expectation bias in the social judgment task. Finally we are interested in how acetaminophen affects crying behaviour as subjectively indicated by the participants. ;Primary end point(s): Cardiac deceleration following unexpected social rejection;Timepoint(s) of evaluation of this end point: 1 hour after ingestion of paracetamol

—

Secondary

Measure	Time frame
Secondary end point(s): Expectancy bias in terms of expected rejection events, P3 amplitude following unexpected rejection and theta power following unexpected social rejection. Subjectively reported crying behavior ;Timepoint(s) of evaluation of this end point: 1 hour after ingestion of paracetamol	—

Countries

Netherlands

Contacts

Public ContactPrincipal Investigator

Erasmus University Rotterdam

veen@fsw.eur.nl104088678

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026