Anaesthesia in adult patients undergoing general surgery
Conditions
Interventions
Pharmaceutical Form: Infusion
INN or Proposed INN: PROPOFOL
CAS Number: 2078-54-8
Other descriptive name: PROPOFOL
Concentration unit: mg/ml milligram(s)/millilitre
Concentration type: range
Concentra
Sponsors
Uppsala University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • Patients scheduled for major elective surgery, i.e. surgery assumed to require more than 1 hour of maintenance of general anesthesia • Scheduled to receive mechanical ventilation via tracheal intubation or laryngeal mask • Age at least 18 years • Willingness and ability to give informed consent, to understand, participate and comply with all study requirements Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 40 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: American association of anaesthesiolgy class >3 Known allergy for any of the anaesthetic agents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To investigate changes in renal function during general anaesthesia.;Secondary Objective: To describe changes in hormonal systems regulating fluid and electrolyte homeostasis during anesthesia Compare sevoflurane and propofol with regards to changes in renal physiology;Primary end point(s): Urine output Creatinine-clearance;Timepoint(s) of evaluation of this end point: During surgery During a two-hour post-operative period During a two-hour period the day after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end point(s): Hormones regulating fluid and electrolyte homeostasis -Plasma arginine vasopressin -Plasma angiotensin II -Plasma aldosteron Renal function -Free water clearance -Urine soidum excretion -Urine potassium excretion;Timepoint(s) of evaluation of this end point: During surgery During a two-hour post-operative period During the day after surgery | — |
Countries
Sweden
Contacts
Public ContactUppsala University Hospital
Uppsala University Hospital
Outcome results
None listed