Effect of sevoflurane and propofol on hepato-splanchnic pressure and flow during hepatobiliary surgery.

Effect of sevoflurane and propofol on hepato-splanchnic pressure and flow during hepatobiliary surgery. - Sevoflurane vs Propofol

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2017-000071-90-BE

Enrollment

Registered

2017-02-13

Start date

2017-03-15

Completion date

Unknown

Last updated

2018-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients scheduled for hepato-biliary surgery.

Interventions

Trade Name: Propolipid 1% emulsie voor injectie of infusie Pharmaceutical Form: Emulsion for injection/infusion INN or Proposed INN: PROPOFOL CAS Number: 2078-54-8 Other descriptive name: PROPOFOL Con

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: • Adult = 18 years (Female or Male) • ASA I – II – III • Able to comprehend, sign and date the written informed consent document to participate in the clinical trial. • Scheduled for hepato-biliary surgery. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 10 F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range 8

Exclusion criteria

Exclusion criteria: • Allergy for the medication • Renal insufficiency (SCr > 2 mg/dl) • Severe heart failure (EF 40

Design outcomes

Primary

Measure	Time frame
Main Objective: Primary objective of the study is to compare the effect of sevoflurane and propofol on hepato-splanchnic pressure and blood flow during hepatobiliary surgery. We hypothesized that sevoflurane induces a dose-dependent reduction of hepato-splanchnic blood flow, while propofol increases hepato-splanchnic blood flow.;Secondary Objective: Secondary objective of the study is to compare the need for inotropic and vasopressor support, the amount of colloids administered and blood loss during surgery between the two study groups.;Primary end point(s): The primary end point is to compare Sevoflurane versus propofol on blood flow in the artery hepatica and main portal vein.;Timepoint(s) of evaluation of this end point: End of the surgery.	—

Measure

Time frame

Main Objective: Primary objective of the study is to compare the effect of sevoflurane and propofol on hepato-splanchnic pressure and blood flow during hepatobiliary surgery. We hypothesized that sevoflurane induces a dose-dependent reduction of hepato-splanchnic blood flow, while propofol increases hepato-splanchnic blood flow.;Secondary Objective: Secondary objective of the study is to compare the need for inotropic and vasopressor support, the amount of colloids administered and blood loss during surgery between the two study groups.;Primary end point(s): The primary end point is to compare Sevoflurane versus propofol on blood flow in the artery hepatica and main portal vein.;Timepoint(s) of evaluation of this end point: End of the surgery.

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Secondary

Measure	Time frame
Secondary end point(s): The secondary end point is to compare Sevoflurane versus propofol the need for inotropic and/or vasopressor support, blood loss and total amount of colloids given.;Timepoint(s) of evaluation of this end point: End of the surgery.	—

Countries

Belgium

Contacts

Public ContactBimetra Clinics

Ghent University Hospital

Bimetra.Clinics@uzgent.be

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026