This trial will be a crossover study of healthy volunteers receiving a warm vs a cold fluid bolus to investigate the difference in hemodynamic response. While this will generate data for future studies in other categories (hypotension, sepsis etc), the volunteers will have no medical conditions.
Conditions
Interventions
Trade Name: Ringer-acetate
Product Name: Ringer acetate
Product Code: ATC kod: B05BB01
Pharmaceutical Form: Solution for injection/infusion
Pharmaceutical form of the placebo: Solution for infusion
R
Sponsors
Karolinska Institutet Södersjukhuset
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy volunteers Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 21 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range 0
Exclusion criteria
Exclusion criteria: Medical disease corresponding to American Society of Anaesthesiology grade II or more
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To determine the difference in cardiac output between the two groups;Secondary Objective: To determine the difference in blood pressure, microcirculation, temperature and duration of these effects;Primary end point(s): Cardiac output;Timepoint(s) of evaluation of this end point: 15 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end point(s): Pulse, blood pressure and temperature changes as well as functional microvessel density. Duration of these;Timepoint(s) of evaluation of this end point: 30, 60 90 and 120 minutes | — |
Countries
Sweden
Contacts
Public ContactKI SÖS
Karolinska Institutet Södersjukhuset
Outcome results
None listed