The behavior of aprepitant in the stomach, small intestine and blood after the oral administration

The gastrointestinal behavior of aprepitant in healthy volunteers

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2016-001156-22-BE

Enrollment

Registered

2016-06-27

Start date

2016-07-19

Completion date

Unknown

Last updated

2020-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy human volunteers (administration of an drug against nausea and vomiting

Interventions

Trade Name: Emend TM Product Name: Emend Product Code: A04AD12 Pharmaceutical Form: Capsule, hard INN or Proposed INN: aprepitant CAS Number: 170729-80-3 Current Sponsor code: MK-0869 Other descripti

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - healthy volunteers - age: 18 - 35 years old Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 5 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: - disease - acute/chronic GI condition - use of medication - pregnancy - frequent exposure to X-rays during the past year - HIV / HBV / HCV infection

Design outcomes

Secondary

Measure	Time frame
Secondary end point(s): not applicable;Timepoint(s) of evaluation of this end point: not applicable	—

Primary

Measure	Time frame
Main Objective: To study the gastrointestinal behavior of aprepitant in healthy volunteers in fasted and fed state;Secondary Objective: Non applicable;Primary end point(s): not applicable ;Timepoint(s) of evaluation of this end point: not applicable	—

Countries

Belgium

Contacts

Public ContactDrug Delivery and Disposition

KU Leuven

philippe.berben@kuleuven.be+3216328729

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026