There are no medical conditions or diseases under investigation, participants are healthy volunteers.
Conditions
Sponsors
Tampere University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet the following criteria: -healthy female subjects -20-40 years old -mothers of children younger than 12 months Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 50 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range 0
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria during a telephone prescreening will be excluded from participation in this study: -Breastfeeding -Any known neurological, visual, and auditory impairment -Use of medication (except oral contraceptives) -Drug or alcohol abuse -Psychiatric disorder -Nasal disease or obstruction -Smoking -Pregnancy -Cardiovascular disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: The primary objective of the study is to study the effects of intranasal OT (vs. placebo) administration to mothers on their neural and behavioral responsivity to children’s emotional signals ;Secondary Objective: The secondary objective of the study is to study the effects of intranasal OT (vs. placebo) administration to mothers on approach-avoidance motivational responses to own vs. unfamiliar child stimuli after contextual priming cues;Primary end point(s): -Event-related potential responses to child and adult facial expression stimuli (N1, N170, EPN, P3, LPP) -Manual reaction times to detect the appearance of a face in the continuous flash suppression paradigm ;Timepoint(s) of evaluation of this end point: Participants will come to the laboratory for two identical experimental sessions, separated by 4 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end point(s): -Asymmetric electroencephalogram (EEG) activity within the alpha frequency band over frontal electrode sites to own and unfamiliar child stimuli. ;Timepoint(s) of evaluation of this end point: Secondary parameters will be assessed during the same two identical experimental sessions, separated by 4 weeks. | — |
Countries
Finland
Contacts
Public ContactTACC/Kaija Puura
Tampere University Hospital
Outcome results
None listed