The influence of dopamine on our reading behavior.

The effect of dopamine on reading motivation and achievement. - Dopamine & Reading

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2014-001352-36-NL

Enrollment

Unknown

Registered

2014-10-07

Start date

2014-12-19

Completion date

Unknown

Last updated

2017-10-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

There are no medical conditions or diseases under investigation.

Interventions

Trade Name: SINEMET 125 Product Name: Sinemet 125 Product Code: RVG 107627//08740 Pharmaceutical Form: Tablet Pharmaceutical form of the placebo: Tablet Route of administration of the placebo: Oral us

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - 18 years or older Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 60 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: - Serious reading problems (dyslexia) - Medical illness, indicating a risk in using haloperidol (e.g., cardiac illness, depression, thyroid disorders, glaucoma) - Current or recent use (<2 weeks before participation) of psycho-pharmacological medication (other than contraceptives), psychotropic drugs or drugs that might interfere with haloperidol. - Known drugs allergies - Pregnancy or lactation

Design outcomes

Primary

Measure	Time frame
Main Objective: The main goal of the study is to investigate if small amounts of dopamine could influence engagement during reading, comprehension of the story and vocabulary learning and to investigate if the effect of dopamine is different for carriers of the long or short variant of the DRD4 gene. Additionally, the effect of dopamine on how participants value reading is investigated. ;Secondary Objective: Not applicable;Primary end point(s): - Task engagement: Index score for task engagement from EEG (beta/(alpha + theta)) - Story comprehension: Results for the comprehension questions - Vocabulary: Results for the vocabulary measure - Reading resistance: Presence or absence of attentional bias for reading related stimuli on the dot-probe task and/or the emotional Stroop task. ;Timepoint(s) of evaluation of this end point: Task engagement is measured during reading. Story comprehension, vocabulary and reading resistance are measured immediatley after reading the text.	—

Measure

Time frame

Main Objective: The main goal of the study is to investigate if small amounts of dopamine could influence engagement during reading, comprehension of the story and vocabulary learning and to investigate if the effect of dopamine is different for carriers of the long or short variant of the DRD4 gene. Additionally, the effect of dopamine on how participants value reading is investigated. ;Secondary Objective: Not applicable;Primary end point(s): - Task engagement: Index score for task engagement from EEG (beta/(alpha + theta)) - Story comprehension: Results for the comprehension questions - Vocabulary: Results for the vocabulary measure - Reading resistance: Presence or absence of attentional bias for reading related stimuli on the dot-probe task and/or the emotional Stroop task. ;Timepoint(s) of evaluation of this end point: Task engagement is measured during reading. Story comprehension, vocabulary and reading resistance are measured immediatley after reading the text.

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Secondary

Measure	Time frame
Secondary end point(s): Not applicable;Timepoint(s) of evaluation of this end point: Not applicable	—

Countries

Netherlands

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026