Does isocapnic hyperventilation hasten early recovery with sevoflurane and desflurane in O2/air?

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2014-000678-20-BE

Enrollment

Registered

2014-08-07

Start date

2014-09-02

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The absence of hypocapnia on the moment of emergence from general inhalatory anesthesia

Interventions

Trade Name: Sevoflurane Product Name: SEVORANE Quick Fill 100% Pharmaceutical Form: Inhalation vapour INN or Proposed INN: Sevoflurane CAS Number: 28523-86-6 Other descriptive name: SEVOFLURANE Concen

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: > 18 years ASA I & II patiënts Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 70 F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range 10

Exclusion criteria

Exclusion criteria: - Pulmonary hypertension - Patients with evidence of coronary (NYHA III) disease - Pulmonary disease (COPD/Asthma) - Right ventricle dysfunction - Psychiatric pathology like syndromes: dementia, schizophrenia, bipolar personality - Daily use of benzodiazepines and/or opioids - Use of psychogenic drugs - Laparoscopies (Abdominal CO2 administration can bias our results) - Pregnant women and breastfeeding women

Design outcomes

Primary

Measure	Time frame
Main Objective: The goal of the study is to examine the effect of hyperventilation on early recovery parameters when sevoflurane or desflurane is used. CO2 will be added to the inspired gas to avoid hypocapnia (“isocapnic hyperventilation”);Secondary Objective: Decrease the length of stay in operating room and hospital.;Primary end point(s): Emergence time from general inhalatory anesthesia after hyperventilation when carbondioxide(CO2) was administrated to maintain alveolar isocapnia.;Timepoint(s) of evaluation of this end point: Opening of the eyes and presence of adequate voluntary minute ventilation.	—

Measure

Time frame

Main Objective: The goal of the study is to examine the effect of hyperventilation on early recovery parameters when sevoflurane or desflurane is used. CO2 will be added to the inspired gas to avoid hypocapnia (“isocapnic hyperventilation”);Secondary Objective: Decrease the length of stay in operating room and hospital.;Primary end point(s): Emergence time from general inhalatory anesthesia after hyperventilation when carbondioxide(CO2) was administrated to maintain alveolar isocapnia.;Timepoint(s) of evaluation of this end point: Opening of the eyes and presence of adequate voluntary minute ventilation.

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Secondary

Measure	Time frame
Secondary end point(s): Perfect statement of their date of birth;Timepoint(s) of evaluation of this end point: The moment of this act	—

Countries

Belgium

Contacts

Public ContactDatanurse

UZ Brussel

veerle.vanmossevelde@uzbrussel.be+3224763134

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026