General anesthesia and oxidative stress
Conditions
Interventions
Trade Name: OXÍGENO MEDICINAL LINDE, gas
medicinal criogénico, 99,5% v/v, en recipientes criogénicos móviles
Pharmaceutical Form: Inhalation vapour, liquid
Sponsors
Institut de Recerca de l?Hospital de la Santa Creu i Sant Pau ? IIB Sant Pau
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients scheduled for elective surgery at the Hospital de la Santa Creu i Sant Pau, ASA 2 or lower, aged between 25 and 50 years, of both sexes. Surgeries where are not expected ventilatory alterations of hemodynamics or major internal environment. This includes ENT surgery, plastic surgery and neck surgery. Surgery with an expected duration of more than 60 minutes. Maintenance anesthesia with sevoflurane. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 60 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range 0
Exclusion criteria
Exclusion criteria: Any decompensated or poorly controlled disease. Women who are pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To evaluate the development of oxidative stress in relation to two oxygen doses frequently administered by anesthesiologists in daily practice, and in situations where surgical conditions are not the main determinant of oxidative stress;Secondary Objective: Not applicable;Primary end point(s): Plasma level of malondialdehide.;Timepoint(s) of evaluation of this end point: 1 hour | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end point(s): Plasma levels of glutation and advanced products of protein oxidation;Timepoint(s) of evaluation of this end point: 1 hour | — |
Countries
Spain
Contacts
Public ContactRomy Rodríguez
Institut de Recerca de l?Hospital de la Santa Creu i Sant Pau
Outcome results
None listed