patients with pulmonary hypertension scheduled for elective minimally invasive mitral valve surgery using heartport technique.
Conditions
Interventions
Trade Name: Chirocaine
Product Name: Chirocaine
Pharmaceutical Form: Solution for injection
INN or Proposed INN: levobupivacaine
CAS Number: 27262-48-2
Other descriptive name: LEVOBUPIVACAINE HYDROCHL
Sponsors
University Hospitals Leuven
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - patient scheduled for minimal invasive mitral valve surgery via right thoracotomy - ASA II - IV - chronic pulmonary hypertensio (systolic PAP >50 mmHg) Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 10 F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range 40
Exclusion criteria
Exclusion criteria: - previous cardiac surgery -contra-indication for TEE - contra-indication for paravertebral block (allergies to local anesthetics, local infection, coagulation disorder, systemic inflammation,...) - Tricupid insufficiency > 1/4 - patient refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: a right paravertebral block does not influence the baseline myocardial performance of both the right and left ventricle in patients with chronically increase right ventricular afterload.;Secondary Objective: A right paravertebral block inhibits the positive inotropic response of the right ventricular to an acute increase in right ventricular afterload;Primary end point(s): Right ventricular function;Timepoint(s) of evaluation of this end point: after insertion of the paravertebral catheter after onset of unilateral sympathetic blockade after 20 min of single lung ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end point(s): no secondary endpoint;Timepoint(s) of evaluation of this end point: not applicable | — |
Countries
Belgium
Contacts
Public ContactResearch Anesthesiology
University Hospitals Leuven
Outcome results
None listed