platelet reactivity
Conditions
Interventions
Trade Name: Aspirin
Product Name: acetylsalicylic acid
Product Code: RVG 16466
Pharmaceutical Form: Tablet
Sponsors
Netherlands Heart Foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • Healthy subject • Age >18yrs • Capacity to give informed consent (IC) Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 11 F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range 1
Exclusion criteria
Exclusion criteria: • Active chronic disease • Use of any other medication • History of: major bleeding events, cardiovascular disease, malignancy • Platelet count < 150 * 109/L • VerifyNow Aspirin Reaction Units <550 ARU • Smoking • Shift workers • Extreme chronotypes • Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To study the effect of 100 mg aspirin intake at bedtime compared with 100 mg aspirin intake on awakening on circadian rhythm of platelet function in healthy subjects.;Secondary Objective: not applicable;Primary end point(s): platelet reactivity, measured by VerifyNow aspirin device;Timepoint(s) of evaluation of this end point: after 2 and 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end point(s): other parameters of platelet function;Timepoint(s) of evaluation of this end point: after 2 and 6 weeks | — |
Countries
Netherlands
Contacts
Public ContactT.N. Bonten
Leiden University Medical Center
Outcome results
None listed