Local anaesthetic injections of the nerves of the upper arm and changes in blood circulation. Comparing effects of lidocain with epinephrine versus without epinephrine.

Plexus brachialis block and circulation. Comparing effects on skin microcirculation and macro circulation of lidocain brachial plexus block with versus without epinephrine.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2012-005651-17-NO

Enrollment

Registered

2013-03-15

Start date

2013-06-13

Completion date

Unknown

Last updated

2025-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

human microcirculation and haemodynamic changes (macrosirculation) in healthy volunteers.

Interventions

Trade Name: Lidocain Pharmaceutical Form: Injection Trade Name: Adrenalin Pharmaceutical Form: Injection

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: We will include 12 healthy volunteers in each study, age 18 – 60, ASA 1-2. Non-smokers. No intake of coffee, black tea or garlic last 12 hours. No regular medication. BMI 18-35. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 12 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range 0

Exclusion criteria

Exclusion criteria: Known allergy against lidocain. Volunteers with neurological decease, diabetes, nerve- or vascular impairment at the upper limb are not included.

Design outcomes

Primary

Measure	Time frame
Main Objective: To establish the effect of epinephrine when added to lidocain in brachial plexus block on human skin microcirculation and haemodynamic changes (macrosirculation) in men.;Secondary Objective: Not applicable;Primary end point(s): Comparing effects on microcirculation and macrocirculation of lidocain brachial plexus block with epinephrine versus without epinephrine.;Timepoint(s) of evaluation of this end point: 40 minutes	—

Measure

Time frame

Main Objective: To establish the effect of epinephrine when added to lidocain in brachial plexus block on human skin microcirculation and haemodynamic changes (macrosirculation) in men.;Secondary Objective: Not applicable;Primary end point(s): Comparing effects on microcirculation and macrocirculation of lidocain brachial plexus block with epinephrine versus without epinephrine.;Timepoint(s) of evaluation of this end point: 40 minutes

—

Secondary

Measure	Time frame
Secondary end point(s): Comparation of different methods for circulation monitoring (laser doppler, temperature, capillary microscopy and spectroscopy, beat-to-beat Finometer measurements).;Timepoint(s) of evaluation of this end point: 40 min	—

Countries

Norway

Contacts

Public ContactDept of anesthesia

Oslo Universitetssykehus

4722119690

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026