Effect of weight-loss induced by a diet on gastrointestinal hormones, bitter taste perception, hunger and gastrointestinal motility during fasting

Effect of diet-induced weight loss on motilin, ghrelin, bitter taste perception, hunger and the migrating motor complex: a prospective study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2012-004600-35-BE

Enrollment

Registered

2012-11-06

Start date

2012-12-19

Completion date

Unknown

Last updated

2022-05-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal contractility and hormones will be studied in obese patients before and after weight loss induced by a diet

Interventions

Trade Name: Erythrocine Pharmaceutical Form: Powder for solution for injection/infusion

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Female or male between 18 and 65 years of age -BMI > 30 kg/m² Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 20 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: - Female volunteers is pregnant or breastfeeding - BMI < 30 kg/m² - Gastrointestinal diseases, major abdominal surgery - Major psychiatric illnesses - Volunteers that use drugs affecting the gastrointestinal tract of the central nervous system - Allergy for macrolide antibiotics - Volunteers that suffer from endocrine diseases

Design outcomes

Primary

Measure	Time frame
Main Objective: Investigating if weight loss induced by a low-caloric diet has an influence on gastrointestinal motility, hormones and hunger;Secondary Objective: Investigating if weight loss induced by a low-caloric diet has an influence on bitter taste perception;Primary end point(s): Contraction pattern induced by erythromycin;Timepoint(s) of evaluation of this end point: Continuous measurement of gastrointestinal motility	—

Measure

Time frame

Main Objective: Investigating if weight loss induced by a low-caloric diet has an influence on gastrointestinal motility, hormones and hunger;Secondary Objective: Investigating if weight loss induced by a low-caloric diet has an influence on bitter taste perception;Primary end point(s): Contraction pattern induced by erythromycin;Timepoint(s) of evaluation of this end point: Continuous measurement of gastrointestinal motility

—

Secondary

Measure	Time frame
Secondary end point(s): NA;Timepoint(s) of evaluation of this end point: NA	—

Countries

Belgium

Contacts

Public ContactEveline Deloose

KULeuven

eveline.deloose@med.kuleuven.be003216330816

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026