Exericise induced bronchoconstriction
Conditions
Interventions
Trade Name: Ventolin
Product Name: Salbutamol
Product Code: R03CC03
Pharmaceutical Form: Inhalation vapour, solution
Pharmaceutical form of the placebo: Nebuliser solution
Route of administration of t
Sponsors
Sportmedisch expertisecentrum
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Age between 18 and 35 years - Elite speedskater - Women: 1500 meter time below 2:10:00 minutes. - Men: 1500 meter time below 02:05:00 minutes. These times should have been skated within a period of two months prior to study measurement. - Able to undergo reproducible lung function tests. Three-fold repetition of FEV1 measurements, with a mutual difference of maximal 5 percent Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 41 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: - Ultrasonic nebulization within 48 hours before testing. - FEV1 <70% of predicted. - Respiratory infection within 6 weeks prior to examination for which medication should be prescribed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Analyze the effect of nebulized salbutamol or isotonic saline on exercise induced airway obstruction measured with a fall in FEV1 in elite speed skaters;Secondary Objective: - Analyze the effect of nebulized salbutamol or isotonic saline on exercise induced airway obstruction measured with a change in airway resistance in elite speed skaters - Analyze the effect of nebulized salbutamol or isotonic saline on exercise induced airway obstruction measured with a change in airway reactance in elite speed skaters - Analyze the effect of nebulized salbutamol or isotonic saline on exercise induced airway obstruction measured with a change in EMG activity or breathing musclesin elite speed skaters;Primary end point(s): -The difference in exercise induced fall of FEV1 after four minutes of treatment with salbutamol compared to nebulization with with salbutamol, 0.9% NaCl and controls.;Timepoint(s) of evaluation of this end point: 10, 15 and 30 minutes after exercise | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end point(s): -Analyze the change in exercise induced increase of airway resistance, measured with the FOT, after four minutes of treatment with salbutamol, 0.9% NaCl and controls. -Analyze the change in exercise induced decrease of airway reactance, measured with the FOT, after four minutes of treatment with salbutamol, 0.9% NaCl and controls. -Analyzing the change in the electro physiological activity of the respiratory muscle system, measured with EMG with Salbutamol ,isotonic saline and controls. ;Timepoint(s) of evaluation of this end point: 10, 15 and 30 minutes after exercise | — |
Countries
Netherlands
Contacts
Public ContactJean Driessen
Sportmedisch Expertisecentrum
Outcome results
None listed