Effect of Adductor-Canal-Blockade on pain, ability to walk and morphine consumption after total knee arthroplasty

Effect of Adductor-Canal-Blockade on postoperative pain, ability to walk and morphine consumption after total knee arthroplasty: A randomised study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2012-002704-41-DK

Enrollment

100

Registered

2012-07-11

Start date

2012-09-18

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment of postoperative pain in patients after total knee arthroplasty

Interventions

Trade Name: Ropivacaine Product Name: Ropivacaine Pharmaceutical Form: Solution for injection CAS Number: 98717-15-8 Other descriptive name: ROPIVACAINE HYDROCHLORIDE Concentration unit: mg/ml milligr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Age > 30 and 18 and =65 years) yes F.1.3.1 Number of subjects for this age range 20

Exclusion criteria

Exclusion criteria: - Unable to corporate. - Unable to speak or understand Danish - Allergy to ropivacaine - Known medical or alcohol-abuse - Known peripheral neuopathy - Daily consumption af strong opioids - Pregnancy

Design outcomes

Primary

Measure	Time frame
Main Objective: Treatment of postoperative pain after total knee arthroplasty;Secondary Objective: no secondary objectives;Primary end point(s): Difference between groups in pain intensity during active 45 degrees knee flexion - 24 hours after surgery, measured on VAS (0-100);Timepoint(s) of evaluation of this end point: 24 hours after last suture	—

Secondary

Measure	Time frame
Secondary end point(s): - Difference between groups (VAS measured at rest as AUC 0-24 hours) at time points: 2, 4, 6, 8, 24 hours postoperatively. - Difference between groups (VAS measured at 45 degrees active knee flexion as AUC 0-24 hours) at time points: 2, 4, 6, 8, 24 postoperative hours. - Time to perform a TUG (Timed Up and Go) test 24 hours after surgery. - Difference between groups in cumulated morphine consumption, first 24 hours. Morphine administered as PCA. - Difference between groups in mean nausea-score at time 2, 4, 6, 8, 24 postoperative hours. - Difference between;Timepoint(s) of evaluation of this end point: 2, 4, 6, 8 and 24 hours after last suture	—

Measure

Time frame

Secondary end point(s): - Difference between groups (VAS measured at rest as AUC 0-24 hours) at time points: 2, 4, 6, 8, 24 hours postoperatively. - Difference between groups (VAS measured at 45 degrees active knee flexion as AUC 0-24 hours) at time points: 2, 4, 6, 8, 24 postoperative hours. - Time to perform a TUG (Timed Up and Go) test 24 hours after surgery. - Difference between groups in cumulated morphine consumption, first 24 hours. Morphine administered as PCA. - Difference between groups in mean nausea-score at time 2, 4, 6, 8, 24 postoperative hours. - Difference between;Timepoint(s) of evaluation of this end point: 2, 4, 6, 8 and 24 hours after last suture

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Countries

Denmark

Contacts

Public ContactClinical Trial Informations

Gentofte Hospital, department of Anaesthesia

ulrik.grevstad@hotmail.com+4539773977

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026