The interaction of intravenous s-ketamine on sevoflurane anesthesia

The effect of intravenous ketamine on the MAC of sevoflurane – a randomized, placebo controlled, double blinded clinical trial - MAC Sevoflurane and intravenous ketamine

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2012-001908-38-AT

Enrollment

120

Registered

2012-06-20

Start date

2012-07-12

Completion date

Unknown

Last updated

2022-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

We want to test if intravenous s-ketamine of two different doses has an effect on MAC of sevoflurane

Interventions

Trade Name: Ketanest S Product Name: Ketanest S Pharmaceutical Form: Injection INN or Proposed INN: ESKETAMINE CAS Number: 33643-46-8 Concentration unit: mg/ml milligram(s)/millilitre Concentration ty

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: elective surgery with general anaesthesia in supine position age 30-65 years skin incision of at least 3 cm at the trunk ASA 1-3 signed informed consent Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 120 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range 0

Exclusion criteria

Exclusion criteria: subjects not able to understand study procedures premedication contraindication for inhalational induction BMI > 30 and < 18,5 patients with significant cardiovascular, respiratory, hepatic or renal disease patients with history of alcohol or drug abuse psychiatric disorders known allergy on ketamine or inhalative anaesthetics pregnancy

Design outcomes

Primary

Measure	Time frame
Main Objective: Does intravenous s-ketamine reduce the MAC value of Sevoflurane;Secondary Objective: Has intravenous ketamine an effect on heart rate, blood pressure and bispectral index monitoring;Primary end point(s): Movement at skin incision;Timepoint(s) of evaluation of this end point: skin incision	—

Secondary

Measure	Time frame
Secondary end point(s): heart rate, blood pressure and bispectral index values at skin incision;Timepoint(s) of evaluation of this end point: skin incision	—

Countries

Austria

Contacts

Public ContactUniversitätsklinik für Anästhesie

Medizinische Universität Wien

ulrike.weber@meduniwien.ac.at0043014040041000

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026