Does genetic variance in the serotonergic system contribute to pain and the efficacy of drug that blocks serotonin?

Does 5-HT polymorphism contribute to pain regulation and efficacy of granisetron? - 5-HT and genetics

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2011-006206-27-SE

Enrollment

Registered

2011-12-27

Start date

2012-02-21

Completion date

Unknown

Last updated

2022-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Experimentally induced muscle pain in healthy volunteers, both sexes and over 18 years of age.

Interventions

Trade Name: Kytril Product Name: Granisetron Pharmaceutical Form: Injection INN or Proposed INN: GRANISETRON HYDROCHLORIDE CAS Number: 107007-99-8 Concentration unit: mg/ml milligram(s)/millilitre Con

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Good general health Age > 18 years No current facial pain Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 70 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Systemic inflammatory connective tissue diseases whiplash-associated disorder fibromyalgia neuropathic pain or neurological disorders use of analgesics

Design outcomes

Primary

Measure	Time frame
Main Objective: To investigate the hypothesis that polymorphisms in e.g. HTR3A, HTR3B, SERT and COMT are of importance for pain regulation and for the efficacy of 5-HT3 antagonists;Secondary Objective: No secondary objectives;Primary end point(s): 50% reduction of maximum pain intensity;Timepoint(s) of evaluation of this end point: 2 min after injection	—

Secondary

Measure	Time frame
Secondary end point(s): Increased pressure pain threshold;Timepoint(s) of evaluation of this end point: 10 and 30 min after injection	—

Countries

Sweden

Contacts

Public ContactDepartment of Dental Medicine

Karolinska Institutet

malin.ernberg@ki.se+4685248 8236

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026