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Effects of the breathing response during reduced oxygentension in inspired air and simultaneous infusion of a neuromuskular blocking agent in patients with obstructive sleep apnea - before and after three months of continous positive airway pressure treatment.

Effect of reduced cholinergic transmission by rocuronium on the hypoxic ventilatory response in patients with obstructive sleep apnea - before and after three months of continous positive airway pressure treatment. A non-radomised, non-blinded study

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
EU CTR
Registry ID
EUCTR2011-005792-16-SE
Enrollment
Unknown
Registered
2012-01-03
Start date
2012-02-10
Completion date
Unknown
Last updated
2012-03-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstuctive sleep apnea and acute hypoxic ventilatory response MedDRA version: 14.1 Level: LLT Classification code 10055577 Term: Obstructive sleep apnea syndrome System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disorders

Interventions

Trade Name: Esmeron Product Name: Esmeron Pharmaceutical Form: Solution for injection/infusion

Sponsors

Karolinska University Hospital
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: Men with diagnosed and untreated moderat obstruktive sleep apnea syndrom (corresponding to AHI (apnea-hypopnea index) 15-30). The men must otherwise be healthy. 18-60 years of age. Non-smokers. BMI =65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Those who do not fulfill the inclusion criterias. Allergy for neuromuscular blocking agents.

Design outcomes

Primary

MeasureTime frame
Main Objective: How does residual neuromuscular blockage effect the acute hypoxic ventilatory response in patients with obstruktive sleep apnea syndrom before and after 3 months of continouse positive airway pressure treatment?;Secondary Objective: 1. How does residual neuromuscular blockage effect the acute hypercarbic ventilatory response in patients with obstruktive sleep apnea syndrom before and after 3 months of treatment? 2. Does temporary use of continouse positive airway pressure compared to ordinary breathing mask effect the acute hypoxic ventilatory response in patients with obstruktive sleep apnea syndrom before and after 3 months of continouse positive airway pressure treatment? 3. Is the acute hypoxic ventilatory response altered by three months of continouse positive airway pressure treatment? 4. Do patients with obstruktive sleep apnea syndrom show signs of obstructed airway at residual neuromuscular blockage when temporary use of continouse positive airway pressure compared is disconnected?;Primary end point(s): Hypoxic ventilatory response. That is the change of minute ventilation (VE) divided by the change in saturation (SpO2).—

Countries

Sweden

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026