The patients who undergo abdominal surgeries (laparotomy or laparoscopy) under desflurane anaesthesia will be investigated. MedDRA version: 14.0 Level: PT Classification code 10018060 Term: General anaesthesia System Organ Class: 10042613 - Surgical and medical procedures MedDRA version: 14.0 Level: LLT Classification code 10014275 Term: EEG System Organ Class: 10022891 - Investigations MedDRA version: 14.0 Level: PT Classification code 10002091 Term: Anaesthesia System Organ Class: 10029205
Conditions
Interventions
Trade Name: Suprane
Product Name: Desflurane
Pharmaceutical Form: Inhalation vapour
Sponsors
Department of Anaesthesia, Tampere University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Obtained written informed consent to assign the study 2. Age range 18-64 years 3. Elective abdominal surgery (laparotomy, laparoscopy) 4. General anaesthesia 5. American Society of Anesthesiologist Classification of Physical Status 3 or less Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 50 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Body mass index more than 30 3. Disease affecting CNS, autonomic nervous system, heart, heart rate, or circulation 4. Chronic use of drugs affecting CNS, autonomic nervous system, heart, heart rate, or circulation; except antihypertensives, which are acceptable in this study 5. Serious psychiatric diseases or disorders 6. Overuse of alcohol 7. Use of illicit drugs 8. Unability of understand, read or use Finnish language 9. History of allergic reactions to any of the drugs used during anaesthesia 10. History or family history of malignant hyperthemia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To analyze physiological reactions to noxious stimuli, i.e., nociception-associated changes in EEG, Entropy and BIS index values, heart rate, or heart rate variability is the main objective.;Secondary Objective: To analyze EEG-arousals caused by noxious stimuli, and that observed during the recovery from general anaestheia.;Primary end point(s): Primary end point is the behaviour of Entropy and BIS index values, raw EEG signal, heart rate, and heart rate variability to the noxious stimuli and the time patients regain consciousness after anaesthesia.;Timepoint(s) of evaluation of this end point: The data will be obtained from the beginning of anaesthesia until the patients showing EEG-arousal after anaesthesia. | — |
Countries
Finland
Contacts
Public ContactTampere University Hospital
Department of Anaesthesia, Tampere University Hospital
Outcome results
None listed