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Nerve Growth Factor (NGF) eye drop administration as visual rescue treatment in visual loss-associated optic gliomas.

Nerve Growth Factor (NGF) eye drop administration as visual rescue treatment in visual loss-associated optic gliomas. - NGF in the optic gliomas

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
EU CTR
Registry ID
EUCTR2011-003030-14-IT
Enrollment
Unknown
Registered
2012-09-03
Start date
2012-09-03
Completion date
Unknown
Last updated
2014-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glioma MedDRA version: 15.0 Level: PT Classification code 10030953 Term: Optic tract glioma System Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)

Interventions

Pharmaceutical Form: Eye drops, emulsion Concentration unit: mg milligram(s) Concentration type: equal Concentration number: 1- Pharmaceutical form of the placebo: Eye drops, emulsion Route of adminis

Sponsors

POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: children with established diagnosis of Optic Gliomas (OG) Are the trial subjects under 18? yes Number of subjects for this age range: 22 F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 2 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: children with OG associated with NF1 in RC treatment or have to finish treatment program till 12 mounths

Design outcomes

Primary

MeasureTime frame
Main Objective: evaluate the efficacy and safety of conjunctivally applied NGF on optic nerve function;Secondary Objective: nd;Primary end point(s): improvment of visual function;Timepoint(s) of evaluation of this end point: 6 months—

Secondary

MeasureTime frame
Secondary end point(s): na;Timepoint(s) of evaluation of this end point: na—

Countries

Italy

Contacts

Public ContactOncologia Pediatrica

Policlinico Gemelli

oncped2@rm.unicatt.it0630155137

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026