Effects of asthma medicine on physical performance in patients with COPD and changes in immune response after exercise

Effects of high dose terbutaline on physical performance in patients with chronic obstructive pulmonary disease and acute inflammatory response after exercise - Effects of terbutaline on patients with COPD

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2011-002987-26-DK

Enrollment

Registered

2011-08-10

Start date

2011-08-24

Completion date

Unknown

Last updated

2012-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

To investigate the effects of terbutaline on repeated exercise performance in patients with chronic obstructive pulmonary disease (COPD). Furthermore to examine the inflammatory response during and after exercise in patients with COPD.

Interventions

Trade Name: Bricanyl Product Name: terbutalin Product Code: R03AC03, R03CC03 Pharmaceutical Form: Powder and solvent for oral solution Pharmaceutical form of the placebo: Nebulisation solution Route o

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: -Sex: Male -Age: 45-75 -COPD classified as GOLD2, with a FEV1 between 30 and 50% -In a physical condition that allows cycling -smoker or former smoker -Informed consent Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 10 F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: -Cardiovascular diseases -Other respiratory diseases than COPD, as well as, lung cancer -Allergy towards the study medicine -Use of beta2-agonist 48 hours prior to study days -COPD rehabilitation 3 months prior to study -Patients treated with beta-blockers

Design outcomes

Primary

Measure	Time frame
Main Objective: The purpose of the study is to investigate the effects of high dose terbutaline on repeated exercise performance in patients with COPD;Secondary Objective: To examine the inflammatory respons during and after exercise in patients with COPD;Primary end point(s): Terbutaline improves repeated cycling performance;Timepoint(s) of evaluation of this end point: appr. 1.5 year from first participant	—

Measure

Time frame

Main Objective: The purpose of the study is to investigate the effects of high dose terbutaline on repeated exercise performance in patients with COPD;Secondary Objective: To examine the inflammatory respons during and after exercise in patients with COPD;Primary end point(s): Terbutaline improves repeated cycling performance;Timepoint(s) of evaluation of this end point: appr. 1.5 year from first participant

—

Secondary

Measure	Time frame
Secondary end point(s): Terbutaline improves skeletal muscle power. Terbutaline increases inflammatory due to larger metabolic stress in working skeletal muscles;Timepoint(s) of evaluation of this end point: appr. 1.5 year from first participant	—

Countries

Denmark

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026