Effect of intravenous lidocaine on propofol narcosis

The interaction of intravenous lidocaine on the Cp50 of propofol for skin incision - Lidocaine and Cp50 of propofol

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2011-000022-29-AT

Enrollment

Registered

2011-09-05

Start date

2011-09-21

Completion date

Unknown

Last updated

2013-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

the effects of intravenous application of lidocaine on the Cp50 during propofol narcosis should be investigated

Interventions

Trade Name: Lidocaine xylocaine 2% Ampullen Product Name: Xylocain Pharmaceutical Form: Concentrate and solvent for solution for injection INN or Proposed INN: LIDOCAINE CAS Number: 137-58-6 Concentra

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: operation under general anaesthesia insertion of LMA possible age 20-60 years ASA 1-2 Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range 36 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: premedication tracheal intubation allergy to lidocaine body mass index > 30 history of esophageal reflux, hiatal hernia, peptic ulcer disease significant cardiovascular, respiratory, renal or hepatic disease history of alcohol or drug abuse pregnancy arrhythmias epilepsy

Design outcomes

Primary

Measure	Time frame
Main Objective: to evaluate the effect of intravenous lidocaine on the Cp50 of propofol;Secondary Objective: to evaluate the effect of intravenous lidocaine on BIS and hemodynamics;Primary end point(s): movement or no movement at skin incision;Timepoint(s) of evaluation of this end point: skin incision	—

Secondary

Measure	Time frame
Secondary end point(s): BIS and hemodynamic changes at skin incision;Timepoint(s) of evaluation of this end point: skin incision	—

Countries

Austria

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026