panic disorder and agoraphobia
Conditions
Sponsors
Charité Universitaetsmedizin Berlin
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Written consent (according to § 40 AMG (1) 3 b) - diagnosis of panic disorder and / or agoraphobia, severity of disease after at least CGI > 3 "mildly ill" - age: 18-65 years - Sufficient ability to communicate with the investigators to answer questions and fill in questionnaires or scales - Negative pregnancy test and safe contraception during the study (defined as the Pearl Index =65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: - Known overreaction after ingestion of D-cycloserine - placement in an institution of judicial or administrative order (according to § 40 AMG (1) 4) - Other psychiatric disorders such as schizophrenia, substance dependence, dementia - Acute Suicidality - epilepsy or other diseases of the central nervous system (brain tumor, encephalitis) - internal diseases such as severe hypertension, congestive heart failure, Zn acute myocardial infarction, cardiac arrhythmia of grade IV or V according to Lown, severe liver or kidney dysfunction, insulin-dependent diabetes, disorders of hematopoiesis - Pregnancy or lactation - changes a psychopharmacotherapy within the last 2 weeks, discontinuation of treatment with psychotropic drugs less than 1 week prior to the study or last-time use of benzodiazepines for less than 4 days - Short-term disturbances of the past day / night cycle - Disorder-specific psychotherapy - Participation within the last month prior to enrollment or during participation in the panic-Cyclo study in another study, AMG - lack of capacity to consent - Medical circumstances which exclude an fMRI study (eg existence of ferromagnetic metal or pacemakers).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Changes in neuronal activation patterns of the three measurements of time in the "Extinction Circuit" (eg amygdala, hippocampus, medial prefrontal cortex);Secondary Objective: Influence of DCS on other relevant neural networks (eg space perception and processing), on Habituation to the scanner measured using fMRI questionnaire, neuropsychological parameter (eg memory) and on conditioning and extinction (contingency interview: ratings of CS + / CS, EDA reaction and behavioral learning curves as a measure of the conditioned response as well as modulation of a neural prediction error signal). ;Primary end point(s): Changes in neuronal activation patterns of the three measurements of time in the "Circuit Extinction"(eg amygdala, hippocampus, medial prefrontal cortex) | — |
Countries
Germany
Outcome results
None listed