(18)F-FDG PET/CT in patients with idiopathic interstitial pneumonias: correlation of tracer uptake and histological findings, and texture-based recognition of usual interstitial pneumonia

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2010-020223-44-AT

Enrollment

Registered

2010-06-29

Start date

2010-08-03

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Interstitial lung disease of unknown etiology

Interventions

Trade Name: (18)F-FDG Product Name: (18)F-FDG Pharmaceutical Form: Solution for injection INN or Proposed INN: FLUORINE (18F) FLUDEOXYGLUCOSE CAS Number: 105851-17-0 Concentration unit: MBq megabecque

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: • symptoms of dyspnea and dry cough • clinical suspicion of an IIP Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: • previous drug therapy of the IIP • pregnancy • inability to understand the study goals or outline, or to consent to participate • age below the specified minimum of 18 years. • at a second time point: absence of tissue alterations, compatible with IIPs, on PET/CT images • at a third time point: patients for whom the suspicion of IIP is not confirmed by biopsy / histological workup

Design outcomes

Primary

Measure	Time frame
Main Objective: To demonstrate the ability of (18)F-FDG PET/CT to detect active disease in patients with idiopathic interstitial pneumonias (IIP). ;Secondary Objective: To determine whether computer-assisted texture-based pattern recognition of PET/CT images can distinguish between usual interstitial pneumonia (UIP) and other IIP subtypes.;Primary end point(s): •Areas with active, histologically verified IIP show a increased tracer uptake in (18)F-FDG PET/CT •Texture-based pattern recognition is able to distinguish between UIP and other IIPs	—

Measure

Time frame

Main Objective: To demonstrate the ability of (18)F-FDG PET/CT to detect active disease in patients with idiopathic interstitial pneumonias (IIP). ;Secondary Objective: To determine whether computer-assisted texture-based pattern recognition of PET/CT images can distinguish between usual interstitial pneumonia (UIP) and other IIP subtypes.;Primary end point(s): •Areas with active, histologically verified IIP show a increased tracer uptake in (18)F-FDG PET/CT •Texture-based pattern recognition is able to distinguish between UIP and other IIPs

—

Countries

Austria

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026