FindTrial
Sign In

Arterial Hypertension in patients with elevated aldosterone to renin ratio but negative confirmatory test for Primary Aldosteronism: comparison between anti-hypertensive efficacy of potassium canrenoate and hydrochlorothiazide - ND

Arterial Hypertension in patients with elevated aldosterone to renin ratio but negative confirmatory test for Primary Aldosteronism: comparison between anti-hypertensive efficacy of potassium canrenoate and hydrochlorothiazide - ND

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
EU CTR
Registry ID
EUCTR2009-017464-17-IT
Enrollment
Unknown
Registered
2010-04-12
Start date
2010-04-15
Completion date
Unknown
Last updated
2012-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arterial hypertension associated with elevated ARR

Interventions

Pharmaceutical Form: Coated tablet INN or Proposed INN: Potassium canrenoate Concentration unit: mg milligram(s) Concentration type: equal Concentration number: 100- Pharmaceutical Form: Tablet INN o

Sponsors

AZIENDA OSPEDALIERA ISTITUTI OSPITALIERI DI VERONA
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: The subjects, male and female over 18 years, will be recruit among hypertensive patients evaluated at the Medicina Interna B Hypertensive Centre, with a negative response to saline inhibitory test Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: 1)Renal failure (creatinine >2 mg/dl) and/or high serum potassium level (> 5.1 mmol/L) 2)Basal pressure >180/110 mmHg 3)Treatment with anti-hypertensive drugs different from drugs allowed before inhibition test 4)Prenancy or feed 5)Age <18 age 6)Pevious intolerance cases to hydrochlorothiazide or canrenoate

Design outcomes

Primary

MeasureTime frame
Main Objective: Evaluate the possible different efficacy of two diuretic treatments ?either hydrochloroyhiazide (HCT) or canrenoate (KA)- in patients with high ARR but negative confirmatory test for Primary Aldosteronism;Secondary Objective: Evaluate: - possible further determinants (apart from ARR) of diuretic efficacy - tollerability of two different treatments, in particular in ione disorder induction and in adverse effects incidence;Primary end point(s): With Altman method, achieve 5 mmHg difference at least in decrease of middle systolic values in 24 hours between two groups—

Countries

Italy

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026