Non invasive imaging of human cartilage by scintigraphy using novel radiolabelled chondroitin sulfate to prove cartilage degeneration in comparision with proteoglycan specific Magnetic Resonance Imaging.

Non invasive imaging of human cartilage by scintigraphy using novel radiopharmaceutical 99mTcCS(chondroitin sulfate) to prove cartilage degeneration (osteoarthritis)in comparision with proteoglycan specific MRI

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2009-016920-30-AT

Enrollment

Registered

2013-09-23

Start date

2013-10-23

Completion date

Unknown

Last updated

2018-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Examination of the fundamental usefulness of 99mTcCS for scintigraphy.

Interventions

Product Name: 99mTcCondrosulf Combination of Condrosulf and 99Mo/99mTc-Generator Pharmaceutical Form: Solution for infusion INN or Proposed INN: Chondroitin sulfate CAS Number: 9007-28-7 Current Spons

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Age between 18 and 90 years - Early arthritis secured by MRI Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: - Pregnancy - Age <18

Design outcomes

Primary

Measure	Time frame
Main Objective: Diagnostic position and/or diagnostic protection in the comparison with MRI of findings;Secondary Objective: -Quantification of degeneration by means of tracer Uptake regulation -Quantification of therapy success after surgical cartilage repair (transplant).;Primary end point(s): -Early recognition of the arthritis in degenerated cartilage (in particular intra articular). -Evaluation of the target-specific enrichment of both tracers in degenerated versus native, hyalinen cartilage fabrics -quantification of the pathological changes by means of determination of the tracer uptakes cartilage fabric -Follow UP investigations concerning treatment success with cartilage transplants after surgical cartilage repair	—

Measure

Time frame

Main Objective: Diagnostic position and/or diagnostic protection in the comparison with MRI of findings;Secondary Objective: -Quantification of degeneration by means of tracer Uptake regulation -Quantification of therapy success after surgical cartilage repair (transplant).;Primary end point(s): -Early recognition of the arthritis in degenerated cartilage (in particular intra articular). -Evaluation of the target-specific enrichment of both tracers in degenerated versus native, hyalinen cartilage fabrics -quantification of the pathological changes by means of determination of the tracer uptakes cartilage fabric -Follow UP investigations concerning treatment success with cartilage transplants after surgical cartilage repair

—

Countries

Austria

Contacts

Public ContactDr. Peter Dolliner

Medizinische Universitaet Wien, Universitaetsklinik fÃ¼r Radiologie und Nuklearmedizin

peter.dolliner@meduniwien.ac.at+431404004357

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026