The influence of propofol and inhalational anesthetics on postoperative pain perception - QST and anesthetics

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2009-016641-26-DE

Enrollment

Registered

2010-04-22

Start date

2010-09-27

Completion date

Unknown

Last updated

2020-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ISensory and pain perception in the skin of patients who receive anesthesia with two different anesthetics for elective surgery will be analyzed.

Interventions

Trade Name: Propofol-Lipuro Pharmaceutical Form: Emulsion for infusion CAS Number: 2078-54-8 Concentration unit: % (W/V) percent weight/volume Concentration type: equal Concentration number: 1- Trade

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Written informed consent obtained prior to study entry including informed consent for genetic research 2. Both genders (male and female) 3. Healthy adults aged =18 to =65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: 1. Involvement in the planning and conduct of the study (applies to staff directly employed at the study site / department) 2. Participation in a clinical study during the last 30 days or use of any other investigational or non-registered drug or vaccine during the study period or within 30 days preceding the first dose of study drugs 3. Age 65 years 4. Any relevant clinical pathological which might affect the study measurements or pharmacokinetics or pharmacodynamics of the tested substances. 5. Any disease affecting central or peripheral nerve system. 6. Any disease in which use of the investigational medicinal products might be contraindicated. 7. Any acute inflammatory disease

Design outcomes

Primary

Measure	Time frame
Main Objective: Comparison of the effect of inhalational anesthetics and propofol on postoperative pain threshold levels. ;Secondary Objective: The secondary objectives of the study are the analysis of postoperative sensory and pain perception in the skin following isoflurane and propofol anesthesia, time course of the development and persistance of postoperative hyperalgesia as well as postoperative analgesic consumption;Primary end point(s): The primary end-point will be the measurement of electrical current under which the stimulation of the sensory nerves is not any more tolerable by the patient.	—

Measure

Time frame

Main Objective: Comparison of the effect of inhalational anesthetics and propofol on postoperative pain threshold levels. ;Secondary Objective: The secondary objectives of the study are the analysis of postoperative sensory and pain perception in the skin following isoflurane and propofol anesthesia, time course of the development and persistance of postoperative hyperalgesia as well as postoperative analgesic consumption;Primary end point(s): The primary end-point will be the measurement of electrical current under which the stimulation of the sensory nerves is not any more tolerable by the patient.

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Countries

Germany

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026