Conditioning with volatile anesthetics in liver transplantation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2009-015890-11-BE

Enrollment

106

Registered

2009-10-14

Start date

2009-11-03

Completion date

Unknown

Last updated

2017-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver transplantation MedDRA version: 12.0 Level: LLT Classification code 10024716 Term: Liver transplantation

Interventions

Trade Name: Sevorane Product Name: sevoflurane Pharmaceutical Form: Inhalation vapour, liquid CAS Number: 28523-86-6 Other descriptive name: SEVOFLURANE Concentration unit: % percent Concentration typ

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Older than 18 years - Patients undergoing liver transplantation - Total or partial cadaveric liver transplantation Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) no F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: - Patients unable to understand the Flemish or Dutch language - Patients with known or suspected allergy to propofol, soja or egg - Patients with norepinephrine infusion above 15 microg/min - Intensive care patients with severe impairment of renal or pulmonary function (e.g. dialysis, hemofiltration, FiO2>0.5)

Design outcomes

Primary

Measure	Time frame
Main Objective: Hypothesis Sevoflurane conditioning, applied as pre- and postconditioning in liver transplant recipients, attenuate ischemic-reperfusion injury compared with the i.v. propofol anesthesia. ;Secondary Objective: Complication score (surgical complications);Primary end point(s): Postoperative peak of the transaminase (AST).	—

Countries

Belgium

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026